MASP2 (protein)
Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene.[1][2][3]
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.[1]
MASP-2 involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.
See also
References
- ^ a b "Entrez Gene: mannan-binding lectin serine peptidase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10747.
- ^ Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC (April 1997). "A second serine protease associated with mannan-binding lectin that activates complement". Nature 386 (6624): 506–10. doi:10.1038/386506a0. PMID 9087411.
- ^ Vorup-Jensen T, Jensenius JC, Thiel S (August 1998). "MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway". Immunobiology 199 (2): 348–57. PMID 9777418.
Further reading
- Petersen SV, Thiel S, Jensenius JC (2001). "The mannan-binding lectin pathway of complement activation: biology and disease association.". Mol. Immunol. 38 (2-3): 133–49. doi:10.1016/S0161-5890(01)00038-4. PMID 11532276.
- Rajaraman P, Brenner AV, Butler MA, et al. (2009). "Common variation in genes related to innate immunity and risk of adult glioma.". Cancer Epidemiol. Biomarkers Prev. 18 (5): 1651–8. doi:10.1158/1055-9965.EPI-08-1041. PMC 2771723. PMID 19423540. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2771723.
- McGeachie M, Ramoni RL, Mychaleckyj JC, et al. (2009). "Integrative predictive model of coronary artery calcification in atherosclerosis.". Circulation 120 (24): 2448–54. doi:10.1161/CIRCULATIONAHA.109.865501. PMC 2810344. PMID 19948975. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2810344.
- Gulla KC, Gupta K, Krarup A, et al. (2010). "Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot.". Immunology 129 (4): 482–95. doi:10.1111/j.1365-2567.2009.03200.x. PMID 20002787.
- Cerhan JR, Novak AJ, Fredericksen ZS, et al. (2009). "Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.". Br. J. Haematol. 145 (5): 614–23. doi:10.1111/j.1365-2141.2009.07675.x. PMC 2820509. PMID 19344414. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2820509.
- Wang Y, Yan J, Shi Y, et al. (2009). "Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection.". BMC Infect. Dis. 9: 51. doi:10.1186/1471-2334-9-51. PMC 2683852. PMID 19405982. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2683852.
- Han S, Lan Q, Park AK, et al. (2010). "Polymorphisms in innate immunity genes and risk of childhood leukemia.". Hum. Immunol. 71 (7): 727–30. doi:10.1016/j.humimm.2010.04.004. PMID 20438785.
- Kocsis A, Kékesi KA, Szász R, et al. (2010). "Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation.". J. Immunol. 185 (7): 4169–78. doi:10.4049/jimmunol.1001819. PMID 20817870.
- Segat L, Milanese M, Pirulli D, et al. (2009). "Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.". J. Gastroenterol. Hepatol. 24 (12): 1840–6. doi:10.1111/j.1440-1746.2009.06009.x. PMID 19817957.
- Smithson A, Perello R, Aibar J, et al. (2010). "Genotypes coding for low serum levels of mannose-binding lectin are underrepresented among individuals suffering from noninfectious systemic inflammatory response syndrome.". Clin. Vaccine Immunol. 17 (3): 447–53. doi:10.1128/CVI.00375-09. PMID 20042521.
- Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2775832.
- Ytting H, Christensen IJ, Steffensen R, et al. (2011). "Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer.". Scand. J. Immunol. 73 (2): 122–7. doi:10.1111/j.1365-3083.2010.02480.x. PMID 21198752.
- Vallès X, Roca A, Lozano F, et al. (2010). "Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency.". Eur. Respir. J. 36 (4): 856–63. doi:10.1183/09031936.00171409. PMID 20150204.
- de Rooij BJ, van Hoek B, ten Hove WR, et al. (2010). "Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation.". Hepatology 52 (3): 1100–10. doi:10.1002/hep.23782. PMID 20593422.
- Rajaraman P, Brenner AV, Neta G, et al. (2010). "Risk of meningioma and common variation in genes related to innate immunity.". Cancer Epidemiol. Biomarkers Prev. 19 (5): 1356–61. doi:10.1158/1055-9965.EPI-09-1151. PMID 20406964.
- Liu JL, Cao C, Ma QJ (2009). "[Study on interaction between SARS-CoV N and MAP19].". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25 (9): 777–9. PMID 19737459.
- St Swierzko A, Cedzynski M, Domzalska-Popadiuk I, et al. (2009). "Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations.". Mol. Immunol. 46 (8-9): 1696–701. doi:10.1016/j.molimm.2009.02.022. PMID 19307021.
- Vallès X, Sarrias MR, Casals F, et al. (2009). "Genetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African children.". Tissue Antigens 74 (4): 298–307. doi:10.1111/j.1399-0039.2009.01328.x. PMID 19775369.
- Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2945168.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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PDB gallery
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1q3x: Crystal structure of the catalytic region of human MASP-2
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1szb: Crystal structure of the human MBL-associated protein 19 (MAp19)
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1zjk: Crystal structure of the zymogen catalytic region of human MASP-2
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factors: Thrombin · Factor VIIa · Factor IXa · Factor Xa · Factor XIa · Factor XIIa · Kallikrein ( PSA, KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK12, KLK13, KLK14, KLK15)
fibrinolysis: Plasmin · Plasminogen activator ( Tissue plasminogen activator · Urinary plasminogen activator)
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B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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